A meta-analysis of induction therapy for advanced thymic epithelial tumors

Masatsugu Hamaji; Syed Osman Ali; Bryan M Burt

doi:10.1016/j.athoracsur.2014.12.048

A meta-analysis of induction therapy for advanced thymic epithelial tumors

Ann Thorac Surg. 2015;99(5):1848-56. doi: 10.1016/j.athoracsur.2014.12.048. Epub 2015 Mar 11.

Authors

Masatsugu Hamaji¹, Syed Osman Ali², Bryan M Burt³

Affiliations

¹ Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan. Electronic address: mhamaji@kuhp.kyoto-u.ac.jp.
² Division of Cardiothoracic Surgery, Altru Hospital, Grand Forks, North Dakota.
³ Division of Thoracic Surgery, Department of Surgery, Baylor College of Medicine, Houston, Texas.

PMID: 25770014
DOI: 10.1016/j.athoracsur.2014.12.048

Abstract

This meta-analysis was designed to determine the effect of induction therapy and surgical resection on overall survival in patients with advanced thymic epithelial tumors. PubMed and Scopus databases were queried, and 12 studies comprising 266 patients were analyzed. Meta-analysis using a random effect model revealed a pooled rate of response to induction therapy of 59%, a pooled rate of complete resection of 73%, and pooled 5-year and 10-year overall survival of 87% and 76% after induction therapy, respectively. Surgical resection after induction therapy for advanced thymic epithelial tumors can be undertaken with favorable outcomes.

Publication types

Meta-Analysis
Review

MeSH terms

Humans
Neoadjuvant Therapy
Neoplasms, Glandular and Epithelial / therapy*
Thymus Neoplasms / therapy*

Supplementary concepts

Thymic epithelial tumor