Long noncoding RNA turnover

Biochimie. 2015 Oct:117:15-21. doi: 10.1016/j.biochi.2015.03.001. Epub 2015 Mar 10.

Abstract

Most RNAs transcribed in mammalian cells lack protein-coding sequences. Among them is a vast family of long (>200 nt) noncoding (lnc)RNAs. LncRNAs can modulate cellular protein expression patterns by influencing the transcription of many genes, the post-transcriptional fate of mRNAs and ncRNAs, and the turnover and localization of proteins. Given the broad impact of lncRNAs on gene regulation, there is escalating interest in elucidating the mechanisms that govern the steady-state levels of lncRNAs. In this review, we summarize our current knowledge of the factors and mechanisms that modulate mammalian lncRNA stability.

Keywords: Long noncoding RNA; RNA-binding protein; Ribonucleoprotein complex.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Humans
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Models, Genetic
  • Protein Binding
  • RNA Stability / genetics*
  • RNA, Long Noncoding / genetics*
  • RNA, Long Noncoding / metabolism
  • RNA-Binding Proteins / metabolism

Substances

  • MicroRNAs
  • RNA, Long Noncoding
  • RNA-Binding Proteins