Trigger chemistries for better industrial formulations

ACS Appl Mater Interfaces. 2015 Apr 1;7(12):6369-82. doi: 10.1021/acsami.5b00485. Epub 2015 Mar 23.

Abstract

In recent years, innovations and consumer demands have led to increasingly complex liquid formulations. These growing complexities have provided industrial players and their customers access to new markets through product differentiation, improved performance, and compatibility/stability with other products. One strategy for enabling more complex formulations is the use of active encapsulation. When encapsulation is employed, strategies are required to effect the release of the active at the desired location and time of action. One particular route that has received significant academic research effort is the employment of triggers to induce active release upon a specific stimulus, though little has translated for industrial use to date. To address emerging industrial formulation needs, in this review, we discuss areas of trigger release chemistries and their applications specifically as relevant to industrial use. We focus the discussion on the use of heat, light, shear, and pH triggers as applied in several model polymeric systems for inducing active release. The goal is that through this review trends will emerge for how technologies can be better developed to maximize their value through industrial adaptation.

Keywords: UV-induced; capsule; depolymerization; polymersome; self-assembly; triggered release.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Capsules / chemistry
  • Chemistry, Pharmaceutical* / methods
  • Pharmaceutical Preparations / chemistry*
  • Polymers / chemistry

Substances

  • Capsules
  • Pharmaceutical Preparations
  • Polymers