Nuclear factor of activated T cells in cancer development and treatment

Jiawei Shou; Jing Jing; Jiansheng Xie; Liangkun You; Zhao Jing; Junlin Yao; Weidong Han; Hongming Pan

doi:10.1016/j.canlet.2015.03.005

Nuclear factor of activated T cells in cancer development and treatment

Cancer Lett. 2015 Jun 1;361(2):174-84. doi: 10.1016/j.canlet.2015.03.005. Epub 2015 Mar 10.

Authors

Jiawei Shou¹, Jing Jing², Jiansheng Xie³, Liangkun You¹, Zhao Jing¹, Junlin Yao¹, Weidong Han⁴, Hongming Pan⁵

Affiliations

¹ Department of Medical Oncology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
² Department of Medical Oncology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
³ Laboratory of Cancer Biology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
⁴ Department of Medical Oncology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Laboratory of Cancer Biology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address: hanwd@zju.edu.cn.
⁵ Department of Medical Oncology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Laboratory of Cancer Biology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

PMID: 25766658
DOI: 10.1016/j.canlet.2015.03.005

Abstract

Since nuclear factor of activated T cells (NFAT) was first identified as a transcription factor in T cells, various NFAT isoforms have been discovered and investigated. Accumulating studies have suggested that NFATs are involved in many aspects of cancer, including carcinogenesis, cancer cell proliferation, metastasis, drug resistance and tumor microenvironment. Different NFAT isoforms have distinct functions in different cancers. The exact function of NFAT in cancer or the tumor microenvironment is context dependent. In this review, we summarize our current knowledge of NFAT regulation and function in cancer development and treatment. NFATs have emerged as a potential target for cancer prevention and therapy.

Keywords: Calcineurin; Drug resistance; Metastasis; NFAT; Tumor microenvironment.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Carcinogenesis
Humans
NFATC Transcription Factors / metabolism*
Neoplasm Metastasis
Neoplasms / drug therapy*
Neoplasms / metabolism*
Neoplasms / pathology
Protein Isoforms
T-Lymphocytes / metabolism
Tumor Microenvironment

Substances

NFATC Transcription Factors
Protein Isoforms