Inflammasomes in aspergillosis--it takes two to tango

Cell Host Microbe. 2015 Mar 11;17(3):290-292. doi: 10.1016/j.chom.2015.02.017.

Abstract

Intracellular inflammasome complexes regulate critical cytokine responses to infections. In this issue of Cell Host & Microbe,Karki et al. (2015) show that protection against the fungus Aspergillus requires the combined efforts of the NLRP3 and AIM2 inflammasomes and involves both caspase-1 and caspase-8.

Publication types

  • Comment

MeSH terms

  • Animals
  • Aspergillus fumigatus / immunology*
  • Carrier Proteins / metabolism*
  • DNA-Binding Proteins / metabolism*
  • Inflammasomes / metabolism*

Substances

  • Carrier Proteins
  • DNA-Binding Proteins
  • Inflammasomes