Hepatoprotective benzofurans and furanolignans from Gymnema tingens

J Asian Nat Prod Res. 2015;17(3):268-73. doi: 10.1080/10286020.2015.1016002.

Abstract

Two new benzofurans, gymnefuranols A (1) and B (2), together with six known furanolignans (3-8), were isolated from Gymnema tingens. The structures of the new compounds were elucidated by comprehensive analysis of the NMR and HR-MS data. Compounds 1, 2, 6, and 7 showed hepatoprotective activities against D-galactosamine-induced HL-7702 cell damage.

Keywords: Asclepiadaceae; Gymnema tingens; benzofuran; furanolignan; hepatoprotective; structure elucidation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzofurans / chemistry
  • Benzofurans / isolation & purification*
  • Benzofurans / pharmacology*
  • Galactosamine / pharmacology
  • Gymnema / chemistry*
  • Lignans / chemistry
  • Lignans / isolation & purification*
  • Lignans / pharmacology*
  • Liver / drug effects*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • Benzofurans
  • Lignans
  • gymnefuranol A
  • gymnefuranol B
  • Galactosamine