lncRNA and gene looping: what's the connection?

Transcription. 2014;5(3):e28658. doi: 10.4161/trns.28658.

Abstract

Recent functional studies have unveiled the significant role chromatin topology plays in gene regulation. Several lines of evidence suggest genes access necessary factors for transcription by forming chromatin loops. A clearer picture of the players involved in chromatin organization, including lncRNA, is emerging.

Keywords: chromatin contact; chromatin loops; eRNA; enhancer; gene regulation; lncRNA; multigene complex; promoter; topologically associating domain; transcription.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • CCCTC-Binding Factor
  • Cell Cycle Proteins / metabolism
  • Chromatin / metabolism*
  • Chromosomal Proteins, Non-Histone / metabolism
  • Cohesins
  • Enhancer Elements, Genetic
  • Gene Expression Regulation*
  • Humans
  • RNA, Long Noncoding / metabolism*
  • Repressor Proteins / metabolism
  • Transcription Initiation, Genetic

Substances

  • CCCTC-Binding Factor
  • CTCF protein, human
  • Cell Cycle Proteins
  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • RNA, Long Noncoding
  • Repressor Proteins