[DNA amplification in the study of polymorphisms linked to the cystic fibrosis gene]

M Claustres; H Bellet; M Desgeorges; P Kjellberg; M F Toueri; B Rollin; H Bonnet

[DNA amplification in the study of polymorphisms linked to the cystic fibrosis gene]

J Genet Hum. 1989 Sep;37(3):243-9.

[Article in French]

Authors

M Claustres, H Bellet, M Desgeorges, P Kjellberg, M F Toueri, B Rollin, H Bonnet

PMID: 2576281

Abstract

The highly specific polymerase chain reaction recently described can be used to amplify selectively several polymorphic regions of DNA genetically close to the cystic fibrosis gene. This method, providing automated, revolutionizes the classical methods of prenatal diagnosis and carrier detection.

Publication types

English Abstract

MeSH terms

Chromosomes, Human, Pair 7
Cystic Fibrosis / genetics*
Genetic Linkage
Humans
Pedigree
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Prenatal Diagnosis