We present a method to selectively (bio)functionalize nanoscale features with the same materials chemistry. It was successfully combined with nanosphere lithography to fabricate and functionalize solid-state nanopores with PEG-brushes, supported lipid membranes, and functional proteins over large areas. The method is inexpensive, can be performed without specialized equipment, and can be applied to both topographic and planar surface modification.
Keywords: PEG brush; nanopore functionalization; nanosphere lithography; solid state nanopore; supported lipid bilayer.