Erroneous HLA typing as a result of acquired uniparental disomy in a patient with acute lymphoblastic leukaemia in peripheral blood complete remission

Blood Transfus. 2015 Oct;13(4):678-81. doi: 10.2450/2015.0236-14. Epub 2015 Jan 29.

Authors

Andrea Bontadini¹, Sandra Iannelli¹, Fiorenza Fruet¹, Simonetta Capelli¹, Riccardo Masetti², Valérie Dubois³, Jean-Marie Tiercy⁴, Arcangelo Prete²

Affiliations

¹ Immunogenetics Unit, Immunohaematology and Transfusion Medicine Service, S. Orsola-Malpighi University Hospital, Bologna, Italy.
² Oncohaematology Paediatric Transplant Unit, S. Orsola-Malpighi University Hospital, Bologna, Italy.
³ HLA Laboratory, EFS Rhone Alpes, France.
⁴ National Reference Laboratory for Histocompatibility, Transplantation Immunology Unit, University Hospital Geneva, Geneva, Switzerland.

No abstract available

Publication types

Case Reports

MeSH terms

Child
Comparative Genomic Hybridization
Gene Dosage
HLA-A1 Antigen / analysis
HLA-A1 Antigen / genetics
HLA-A3 Antigen / analysis
HLA-A3 Antigen / genetics*
Histocompatibility Testing*
Humans
Loss of Heterozygosity*
Male
Polymerase Chain Reaction / methods*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood
Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology*
Siblings
Uniparental Disomy / genetics
Uniparental Disomy / immunology*

Substances

HLA-A*01:01 antigen
HLA-A*03 antigen
HLA-A1 Antigen
HLA-A3 Antigen