Five new benzylphenanthrenes from Cremastra appendiculata

Fitoterapia. 2015 Jun:103:27-32. doi: 10.1016/j.fitote.2015.03.003. Epub 2015 Mar 7.

Abstract

Five new benzylphenanthrenes, cremaphenanthrenes L-P (1-5) were isolated from the EtOAc-soluble extract of the tubers of Cremastra appendiculata. Their structures were elucidated based on the spectroscopic data and chemical methods. Compounds 1-5 were tested in vitro for their cytotoxic effects against colon (HCT-116), cervix (Hela), and breast (MCF-7 and MDA-MB-231) cancer cell lines. Compound 1 showed moderate cytotoxic activities against HCT-116, MCF-7, and MDA-MB-231 cancer cell lines with IC50 values ranging from 15.84 to 24.18 μM and weak cytotoxicity to Hela cell line with IC50 value of 68.81 μM.

Keywords: Benzylphenanthrene; Cremastra appendiculata; Cytotoxic activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Cell Line, Tumor
  • Humans
  • Molecular Structure
  • Orchidaceae / chemistry*
  • Phenanthrenes / chemistry*
  • Plant Extracts / chemistry*
  • Plant Tubers / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Phenanthrenes
  • Plant Extracts