Tirucallane-type triterpenoids from the fruit of Ficus carica and their cytotoxic activity

Chem Pharm Bull (Tokyo). 2015;63(3):237-43. doi: 10.1248/cpb.c14-00779.

Abstract

Nine new tirucallane-type triterpenoids, ficutirucins A-I (1-9), were isolated from the fruit of Ficus carica. Their structures were established on the basis of spectroscopic data and chemical methods. All isolates were evaluated for their cytotoxic activities against three human cancer cell lines, MCF-7, HepG-2, and U2OS. Compounds 1-3, 6, 7, and 9 exhibited moderate cytotoxic activities with IC50 values of 11.67-45.61 µM against one or more of the three cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cytotoxins / chemistry
  • Cytotoxins / isolation & purification*
  • Cytotoxins / pharmacology
  • Ficus*
  • Fruit*
  • Hep G2 Cells
  • Humans
  • MCF-7 Cells
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification*
  • Plant Extracts / pharmacology
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology

Substances

  • Cytotoxins
  • Plant Extracts
  • Triterpenes
  • tirucallane