Abstract
Photodynamic therapy is a promising treatment method, but its applications are limited by the shallow penetration of visible light. Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.
Keywords:
X-PDT; cancer treatment; nanomedicine; nanoscintillator; radioluminescence nanophosphors; singlet oxygen.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Cell Survival / drug effects
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Cell Survival / radiation effects
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Delayed-Action Preparations / administration & dosage*
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Delayed-Action Preparations / chemistry
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Delayed-Action Preparations / radiation effects
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Light
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Nanocapsules / chemistry
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Nanocapsules / radiation effects*
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Nanocapsules / ultrastructure
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Neoplasms, Experimental / drug therapy*
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Neoplasms, Experimental / pathology
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Photochemotherapy / methods*
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Photosensitizing Agents / administration & dosage*
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Photosensitizing Agents / chemistry
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Treatment Outcome
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X-Ray Therapy / methods
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X-Rays
Substances
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Delayed-Action Preparations
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Nanocapsules
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Photosensitizing Agents