Functions and Mechanisms of Long Noncoding RNAs in Ovarian Cancer

Int J Gynecol Cancer. 2015 May;25(4):566-9. doi: 10.1097/IGC.0000000000000413.

Abstract

Long noncoding RNAs (lncRNAs) are longer than 200-nucleotide, noncoding transcripts in length, have a variety of biological functions, and are closely associated with tumor development. Ovarian cancer, as 1 of the 3 common gynecological malignancies, is the leading cause of death in women with gynecological malignant tumor. In this study, a review of the literature found that lncRNAs H19, LSINCT5, and XIST have a close relationship to the development of ovarian cancer occurrence, growth, invasion, and metastasis, and they can promote ovarian cancer cell proliferation. Hence, in this article, the progress of above-mentioned 3 kinds of lncRNAs in ovarian cancer was reviewed and designed to help in the diagnosis, treatment, and prognosis of ovarian cancer.

Publication types

  • Review

MeSH terms

  • Animals
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Ovarian Neoplasms / genetics*
  • RNA, Long Noncoding / genetics*

Substances

  • RNA, Long Noncoding