We presented a case of mixed endometrial stromal sarcoma and smooth muscle cell tumor of the uterus with intravenous metastasis into the right heart. 50 hot mutated key genes of solid tumors were detected by next generation sequencing. The literature about the diagnostic and therapeutic strategies of the disease were reviewed.
Keywords: Mixed endometrial stromal and smooth muscle tumor; gene; intracardiac metastasis; next-generation sequencing; uterus.