Long noncoding RNAs: novel players in colorectal cancer

Dong Han; Meng Wang; Ning Ma; Ya Xu; Yuting Jiang; Xu Gao

doi:10.1016/j.canlet.2015.03.002

Long noncoding RNAs: novel players in colorectal cancer

Cancer Lett. 2015 May 28;361(1):13-21. doi: 10.1016/j.canlet.2015.03.002. Epub 2015 Mar 6.

Authors

Dong Han¹, Meng Wang², Ning Ma³, Ya Xu³, Yuting Jiang³, Xu Gao⁴

Affiliations

¹ Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China; Heilongjiang Medical Science Academy, Harbin, China.
² Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
³ Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.
⁴ Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China. Electronic address: gaoxu_671227@163.com.

PMID: 25754818
DOI: 10.1016/j.canlet.2015.03.002

Abstract

Colorectal cancer (CRC) is the most common type of cancer in the world. Despite its commonness, the underlying mechanism of CRC is not completely understood. Long noncoding RNAs (lncRNAs) have received increased attention with the development of whole genome and transcriptome sequencing technologies. Recent findings reveal that lncRNAs are implicated in serial steps of cancer development. These lncRNAs interact with DNA, RNA, protein molecules and/or their combinations, acting as an essential regulator in chromatin organization, and transcriptional and post-transcriptional regulation. In this review, we highlight recent findings of emerging roles for lncRNAs in CRC and discuss rapid translational lncRNA research for clinical application in diagnosis, prognosis and potential treatment.

Keywords: Colorectal cancer (CRC); Long noncoding RNAs; Therapeutic targets; Tumorigenesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Colorectal Neoplasms / genetics*
Colorectal Neoplasms / pathology*
Gene Expression Regulation, Neoplastic*
Humans
RNA, Long Noncoding / genetics*

Substances

RNA, Long Noncoding