Synthesis and antimicrobial activity of amino linked heterocycles

Chem Pharm Bull (Tokyo). 2015;63(2):75-80. doi: 10.1248/cpb.c14-00521.

Abstract

Amino-linked benzoxazolyl/benzothiazolyl/benzimidazolyl quinazolines were prepared and their antimicrobial activity studied. The nitro-substituted benzothiazolyl quinazoline (8f) may be a potential antibacterial agent against Staphylococcus aureus and nitro-substituted benzimidazolyl quinazoline (9f) may be a potential antifungal agent against Aspergillus niger.

MeSH terms

  • Amines / chemistry
  • Anti-Infective Agents / chemical synthesis*
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology*
  • Aspergillus niger / drug effects*
  • Benzimidazoles / chemistry
  • Benzothiazoles / chemistry
  • Benzoxazoles / chemistry
  • Gram-Negative Bacteria / drug effects*
  • Gram-Positive Bacteria / drug effects*
  • Microbial Sensitivity Tests
  • Quinazolines / chemistry*
  • Staphylococcus aureus / drug effects

Substances

  • Amines
  • Anti-Infective Agents
  • Benzimidazoles
  • Benzothiazoles
  • Benzoxazoles
  • Quinazolines