Parenchymal lung changes on computed tomography after stereotactic radiotherapy using high dose rate flattening filter free beams

Max Dahele; John R van Sörnsen de Koste; Peter M van de Ven; Femke Spoelstra; Ben Slotman; Suresh Senan

doi:10.1016/j.radonc.2015.02.012

Parenchymal lung changes on computed tomography after stereotactic radiotherapy using high dose rate flattening filter free beams

Radiother Oncol. 2015 Mar;114(3):357-60. doi: 10.1016/j.radonc.2015.02.012. Epub 2015 Mar 4.

Authors

Max Dahele¹, John R van Sörnsen de Koste², Peter M van de Ven³, Femke Spoelstra², Ben Slotman², Suresh Senan²

Affiliations

¹ Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: m.dahele@vumc.nl.
² Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands.
³ Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands.

PMID: 25746351
DOI: 10.1016/j.radonc.2015.02.012

Abstract

Flattening filter free (FFF) beams allow fast delivery of stereotactic radiotherapy. To evaluate biological effects of FFF in lung, we compared parenchymal changes after FFF and non-FFF stereotactic volumetric modulated arc therapy. Standardized multi-observer consensus evaluation of follow-up CT scans revealed no major differences between FFF and non-FFF.

Keywords: Follow up; Lung cancer; Lung changes; Stereotactic radiotherapy; Toxicity.

MeSH terms

Aged
Female
Filtration
Humans
Imaging, Three-Dimensional
Lung / diagnostic imaging*
Lung Neoplasms / radiotherapy*
Male
Radiotherapy Planning, Computer-Assisted / methods
Radiotherapy, Intensity-Modulated / methods
Tomography, X-Ray Computed