Cerium fluoride nanoparticles protect cells against oxidative stress

Alexander B Shcherbakov; Nadezhda M Zholobak; Alexander E Baranchikov; Anastasia V Ryabova; Vladimir K Ivanov

doi:10.1016/j.msec.2015.01.094

Cerium fluoride nanoparticles protect cells against oxidative stress

Mater Sci Eng C Mater Biol Appl. 2015 May:50:151-9. doi: 10.1016/j.msec.2015.01.094. Epub 2015 Feb 2.

Authors

Alexander B Shcherbakov¹, Nadezhda M Zholobak¹, Alexander E Baranchikov², Anastasia V Ryabova³, Vladimir K Ivanov⁴

Affiliations

¹ Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv D0368, Ukraine.
² Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow 119991, Russia.
³ Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow 115409, Russia.
⁴ Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow 119991, Russia; National Research Tomsk State University, Tomsk 634050, Russia. Electronic address: van@igic.ras.ru.

PMID: 25746257
DOI: 10.1016/j.msec.2015.01.094

Abstract

A novel facile method of non-doped and fluorescent terbium-doped cerium fluoride stable aqueous sols synthesis is proposed. Intense green luminescence of CeF3:Tb nanoparticles can be used to visualize these nanoparticles' accumulation in cells using confocal laser scanning microscopy. Cerium fluoride nanoparticles are shown for the first time to protect both organic molecules and living cells from the oxidative action of hydrogen peroxide. Both non-doped and terbium-doped CeF3 nanoparticles are shown to provide noteworthy protection to cells against the vesicular stomatitis virus.

Keywords: Cerium fluoride nanoparticles; Living cells; Luminescence; Oxidative stress; Terbium doped CeF(3); Toxicity; Virus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiviral Agents / pharmacology
Cell Line
Cell Survival / drug effects
Cerium / pharmacology*
Cerium / toxicity
Coloring Agents / chemistry
Cytopathogenic Effect, Viral / drug effects
Cytoprotection / drug effects*
Fluorides / pharmacology*
Fluorides / toxicity
Hydrogen Peroxide / metabolism
Kinetics
Luminescence
Microscopy, Confocal
Nanoparticles / chemistry*
Nanoparticles / ultrastructure
Oxidation-Reduction / drug effects
Oxidative Stress / drug effects*
Particle Size
Spectrometry, Fluorescence
Spectrophotometry, Ultraviolet
Sus scrofa
Terbium / chemistry
Vesiculovirus / drug effects

Substances

Antiviral Agents
Coloring Agents
Terbium
cerium fluoride
Cerium
Hydrogen Peroxide
Fluorides