Molecular epidemiology study of swine influenza virus revealing a reassorted virus H1N1 in swine farms in Cuba

Prev Vet Med. 2015 May 1;119(3-4):172-8. doi: 10.1016/j.prevetmed.2015.02.013. Epub 2015 Feb 23.

Abstract

In this report, we describe the emergence of reassorted H1N1 swine influenza virus, originated from a reassortment event between the H1N1 pandemic influenza virus (H1N1p/2009) and endemic swine influenza virus in Cuban swine population. In November 2010, a clinical respiratory outbreak was reported on a pig fattening farm in Cuba. Phylogenetic analysis showed that all the genes of one of the isolate obtained, with the exception of neuraminidase, belonged to the H1N1p/2009 cluster. This finding suggests that H1N1pdm has been established in swine and has become a reservoir of reassortment that may produce new viruses with both animal and public health risks.

Keywords: Phylogenetic analysis; Reassortant; Swine influenza virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cuba / epidemiology
  • Genome, Viral*
  • Hemagglutinin Glycoproteins, Influenza Virus / genetics
  • Hemagglutinin Glycoproteins, Influenza Virus / metabolism
  • Influenza A Virus, H1N1 Subtype / genetics*
  • Influenza A Virus, H1N1 Subtype / metabolism
  • Molecular Sequence Data
  • Orthomyxoviridae Infections / epidemiology*
  • Orthomyxoviridae Infections / genetics
  • Orthomyxoviridae Infections / virology
  • Phylogeny
  • Swine
  • Swine Diseases / epidemiology*
  • Swine Diseases / genetics
  • Swine Diseases / virology

Substances

  • H1N1 virus hemagglutinin
  • Hemagglutinin Glycoproteins, Influenza Virus

Associated data

  • GENBANK/HE589463
  • GENBANK/HE589464
  • GENBANK/HE589465
  • GENBANK/HE589466
  • GENBANK/HE589467
  • GENBANK/HE589468
  • GENBANK/HE589469
  • GENBANK/HE589470