Short circuiting the circadian system with a new generation of precision tools

Dawn H Loh; Takashi Kudo; Christopher S Colwell

doi:10.1016/j.neuron.2015.02.037

Short circuiting the circadian system with a new generation of precision tools

Neuron. 2015 Mar 4;85(5):895-8. doi: 10.1016/j.neuron.2015.02.037.

Authors

Dawn H Loh¹, Takashi Kudo¹, Christopher S Colwell²

Affiliations

¹ Laboratory of Circadian and Sleep Medicine, Department of Psychiatry, Semel Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.
² Laboratory of Circadian and Sleep Medicine, Department of Psychiatry, Semel Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA. Electronic address: ccolwell@mednet.ucla.edu.

PMID: 25741718
DOI: 10.1016/j.neuron.2015.02.037

Abstract

Circadian behavior in mammals is coordinated by neurons within the suprachiasmatic nucleus (SCN). In this issue, Lee et al. (2015) and Mieda et al. (2015) applied state-of-the-art genetic tools to dissect the microcircuits within the SCN generating circadian rhythmic behavior.

Publication types

Comment

MeSH terms

ARNTL Transcription Factors / deficiency*
Animals
Arginine Vasopressin / metabolism*
Circadian Clocks / physiology*
Circadian Rhythm / physiology*
Interneurons / physiology*
Neurons / physiology*
Neuropeptides / biosynthesis*
Suprachiasmatic Nucleus / physiology*

Substances

ARNTL Transcription Factors
Bmal1 protein, mouse
Neuropeptides
neuromedin S
Arginine Vasopressin