Motility disorders, functional gastrointestinal disorders, inflammatory bowel disease and cardiac rhythm disturbances - is there a link? Review of literature

Curr Drug Targets. 2015;16(3):189-93. doi: 10.2174/1389450116666150304104453.

Abstract

Gastrointestinal disorders are frequently accompanied by symptoms exceeding gastrointestinal tract. This is at least partially connected with the involvement of autonomic nervous system in pathophysiology of diseases such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) or spectrum of motility disorders. In light of the above, involvement of cardiovascular system in natural history of gastrointestinal disorders seems to be of interest. On the other hand, available data regarding the prevalence of cardiac rhythm disturbances in IBD, IBS and motility disorders is limited. What is more, pharmacotherapy of the mentioned diseases includes drugs with possible arrhythmogenic potential. In this review we present current experiences and observations concerning gastrointestinal disorders and cardiac rhythm disturbances.

Publication types

  • Review

MeSH terms

  • Animals
  • Arrhythmias, Cardiac / chemically induced
  • Arrhythmias, Cardiac / diagnosis*
  • Arrhythmias, Cardiac / epidemiology
  • Cardiotonic Agents / adverse effects*
  • Gastrointestinal Diseases / chemically induced
  • Gastrointestinal Diseases / diagnosis*
  • Gastrointestinal Diseases / epidemiology
  • Gastrointestinal Motility* / drug effects
  • Humans
  • Inflammatory Bowel Diseases / chemically induced
  • Inflammatory Bowel Diseases / diagnosis*
  • Inflammatory Bowel Diseases / epidemiology

Substances

  • Cardiotonic Agents