Vessel network formation in response to intermittent hypoxia is frequency dependent

J Biosci Bioeng. 2015 Sep;120(3):347-50. doi: 10.1016/j.jbiosc.2015.01.017. Epub 2015 Feb 24.

Abstract

A combined experimental and mathematical model of intermittent hypoxia (IH) conditioned engineered tissue was used to characterize the effects of IH on the formation of in vitro vascular networks. Results showed that the frequency of hypoxic oscillations has pronounced influence on the vascular response of endothelial cells and fibroblasts.

Keywords: 3D culture; Endothelial cells; Intermittent hypoxia; Oxygen; Vascular endothelial growth factor; Vasculogenesis.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Blood Vessels / cytology*
  • Blood Vessels / drug effects
  • Blood Vessels / metabolism
  • Cell Proliferation / drug effects
  • Endothelial Cells / cytology
  • Endothelial Cells / drug effects
  • Endothelial Cells / metabolism
  • Fetal Blood / cytology
  • Fibroblasts / cytology
  • Fibroblasts / drug effects
  • Fibroblasts / metabolism
  • Humans
  • Hypoxia / metabolism*
  • Models, Biological
  • Oxygen / metabolism
  • Oxygen / pharmacology
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Vascular Endothelial Growth Factor A
  • Oxygen