Abstract
Blueberries (Vaccinium spp.) are rich in bioactive compounds. However, the biological activity of polysaccharides from blueberry has not been reported so far. This study evaluated the anti-tumor and immunological activities of a polysaccharide (BBP3-1) from blueberry in S180-bearing mice. The experimental results indicated that BBP3-1 (100 mg·kg-1·d-1) inhibited the tumor growth rate by 73.4%. Moreover, this group, compared with the model control, had shown an effect of increasing both the spleen and thymus indices (p < 0.05), increasing phagocytosis by macrophages (p < 0.05), boosting the proliferation and transformation of lymphocytes (p < 0.01), promoting the secretion of TNF-α, IFN-γ, and IL-2 (p < 0.05) and improving NK cell activity (p < 0.01). From this study, we could easily conclude that BBP3-1 has the ability to inhibit tumor progression and could act as a good immunomodulator.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antineoplastic Agents / immunology
-
Antineoplastic Agents / pharmacology*
-
Biological Factors / immunology
-
Biological Factors / pharmacology*
-
Blueberry Plants / chemistry*
-
Cell Line, Tumor
-
Cell Proliferation / drug effects
-
Female
-
Immunologic Factors / immunology
-
Immunologic Factors / pharmacology
-
Interferon-gamma / immunology
-
Interleukin-2 / immunology
-
Killer Cells, Natural / drug effects
-
Killer Cells, Natural / immunology
-
Macrophages / drug effects
-
Macrophages / immunology
-
Mice
-
Phagocytosis / drug effects
-
Plant Extracts / immunology
-
Plant Extracts / pharmacology
-
Polysaccharides / immunology
-
Polysaccharides / pharmacology*
-
Tumor Necrosis Factor-alpha / immunology
Substances
-
Antineoplastic Agents
-
Biological Factors
-
Immunologic Factors
-
Interleukin-2
-
Plant Extracts
-
Polysaccharides
-
Tumor Necrosis Factor-alpha
-
Interferon-gamma