Impact of β-lactamase inhibition on the activity of ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus

Antimicrob Agents Chemother. 2015 May;59(5):2938-41. doi: 10.1128/AAC.05080-14. Epub 2015 Mar 2.

Abstract

The production of β-lactamases Bla(Mab) and BlaC contributes to β-lactam resistance in Mycobacterium abscessus and Mycobacterium tuberculosis, respectively. Ceftaroline was efficiently hydrolyzed by these enzymes. Inhibition of M. tuberculosis BlaC by clavulanate decreased the ceftaroline MIC from ≥ 256 to 16 to 64 μg/ml, but these values are clinically irrelevant. In contrast, the ceftaroline-avibactam combination should be evaluated against M. abscessus since it inhibited growth at lower and potentially achievable drug concentrations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azabicyclo Compounds / pharmacology
  • Ceftaroline
  • Cephalosporins / pharmacology*
  • Mycobacterium / drug effects*
  • Mycobacterium / enzymology
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / enzymology*
  • beta-Lactamase Inhibitors / pharmacology
  • beta-Lactamases / metabolism

Substances

  • Azabicyclo Compounds
  • Cephalosporins
  • beta-Lactamase Inhibitors
  • avibactam
  • beta-Lactamases