Influence of inflammation on voriconazole metabolism

M A Encalada Ventura; L F R Span; E R van den Heuvel; G M M Groothuis; J-W C Alffenaar

doi:10.1128/AAC.04789-14

Influence of inflammation on voriconazole metabolism

Antimicrob Agents Chemother. 2015 May;59(5):2942-3. doi: 10.1128/AAC.04789-14. Epub 2015 Mar 2.

Authors

M A Encalada Ventura¹, L F R Span², E R van den Heuvel³, G M M Groothuis⁴, J-W C Alffenaar⁵

Affiliations

¹ University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, the Netherlands University of Groningen, Department of Pharmacy, Division of Pharmacokinetics, Toxicology and Targeting, Groningen, the Netherlands.
² University of Groningen, University Medical Center Groningen, Department of Hematology, Groningen, the Netherlands.
³ Eindhoven University of Technology, Department of Mathematics and Computer Science, Eindhoven, the Netherlands.
⁴ University of Groningen, Department of Pharmacy, Division of Pharmacokinetics, Toxicology and Targeting, Groningen, the Netherlands.
⁵ University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, the Netherlands j.w.c.alffenaar@umcg.nl.

Abstract

Voriconazole pharmacokinetics shows a large inter- and intrapatient variability. Inflammation is associated with changes in the expression of CYP isoenzymes. Here, we evaluated the influence of inflammation, marked by C-reactive protein (CRP) levels in blood, on the metabolism of voriconazole. Observational data showed an association between CRP level and the ratio of voriconazole N-oxide to voriconazole.

MeSH terms

C-Reactive Protein / metabolism
Inflammation / metabolism*
Voriconazole / metabolism*
Voriconazole / pharmacokinetics

Substances

C-Reactive Protein
Voriconazole