Fighting an old disease with next-generation sequencing

Elife. 2015 Mar 3:4:e06782. doi: 10.7554/eLife.06782.

Abstract

Whole genome sequencing has revealed that most cases of tuberculosis in a high-incidence setting in Malawi were caused by just one lineage of the bacterium responsible for the disease.

Keywords: Malawi; epidemiology; global health; transmission; tuberculosis.

MeSH terms

  • Genes, Bacterial
  • High-Throughput Nucleotide Sequencing*
  • Humans
  • Mycobacterium tuberculosis / genetics
  • Tuberculosis / genetics
  • Tuberculosis / microbiology*