Characterization of Brønsted acid-base complexes by ¹⁹F DOSY

Hariharaputhiran Subramanian; Craig P Jasperse; Mukund P Sibi

doi:10.1021/acs.orglett.5b00297

Characterization of Brønsted acid-base complexes by ¹⁹F DOSY

Org Lett. 2015 Mar 20;17(6):1429-32. doi: 10.1021/acs.orglett.5b00297. Epub 2015 Mar 2.

Authors

Hariharaputhiran Subramanian¹, Craig P Jasperse², Mukund P Sibi¹

Affiliations

¹ †Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota 58108, United States.
² ‡Department of Chemistry, Minnesota State University, Moorhead, Minnesota 56563, United States.

PMID: 25730425
DOI: 10.1021/acs.orglett.5b00297

Abstract

A (19)F DOSY protocol for the determination of formula weights for acid-base complexes in solution has been developed. (19)F internal standards were chosen and were used to evaluate the formula weights of complexes in solution using simple diffusion coefficient (D)-formula weight (FW) analysis. This method has potential applications in characterization of reactive intermediates in catalytic asymmetric reactions.