Gaseous modulators in the control of the hypothalamic neurohypophyseal system

Physiology (Bethesda). 2015 Mar;30(2):127-38. doi: 10.1152/physiol.00040.2014.

Abstract

Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are gaseous molecules produced by the brain. Within the hypothalamus, gaseous molecules have been highlighted as autocrine and paracrine factors regulating endocrine function. Therefore, in the present review, we briefly discuss the main findings linking NO, CO, and H2S to the control of body fluid homeostasis at the hypothalamic level, with particular emphasis on the regulation of neurohypophyseal system output.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autocrine Communication
  • Carbon Monoxide / metabolism*
  • Gases
  • Humans
  • Hydrogen Sulfide / metabolism*
  • Hypothalamo-Hypophyseal System / metabolism*
  • Hypothalamo-Hypophyseal System / physiopathology
  • Nitric Oxide / metabolism*
  • Paracrine Communication
  • Signal Transduction*
  • Water-Electrolyte Balance*
  • Water-Electrolyte Imbalance / metabolism*
  • Water-Electrolyte Imbalance / physiopathology

Substances

  • Gases
  • Nitric Oxide
  • Carbon Monoxide
  • Hydrogen Sulfide