Key stages of bone marrow B-cell maturation are defective in patients with common variable immunodeficiency disorders

J Allergy Clin Immunol. 2015 Aug;136(2):487-90.e2. doi: 10.1016/j.jaci.2014.12.1943. Epub 2015 Feb 26.

Affiliations

¹ Nuffield Department of Medicine, University of Oxford, Oxford University Hospital, Headley Way, Oxford, United Kingdom.
² Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Hospital, Oxford, United Kingdom.
³ Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
⁴ Nuffield Department of Medicine, University of Oxford, Oxford University Hospital, Headley Way, Oxford, United Kingdom. Electronic address: helen.chapel@ndm.ox.ac.uk.

PMID: 25725990
DOI: 10.1016/j.jaci.2014.12.1943

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antigens, CD / genetics
Antigens, CD / immunology
Bone Marrow Cells / immunology
Bone Marrow Cells / pathology*
Bronchiectasis / complications
Bronchiectasis / genetics
Bronchiectasis / immunology
Bronchiectasis / pathology*
Cell Differentiation
Common Variable Immunodeficiency / complications
Common Variable Immunodeficiency / genetics
Common Variable Immunodeficiency / immunology
Common Variable Immunodeficiency / pathology*
Female
Gene Expression
Hematopoiesis / immunology
Humans
Lymphocyte Activation
Male
Middle Aged
Precursor Cells, B-Lymphoid / immunology
Precursor Cells, B-Lymphoid / pathology*
Thrombocytopenia / complications
Thrombocytopenia / genetics
Thrombocytopenia / immunology
Thrombocytopenia / pathology*

Substances

Antigens, CD