Abstract
Systemic TNF-α expression is increased in a subset of children with moderate-to-severe asthma despite aggressive corticosteroid treatment and is associated with poor asthma control. Phenotypic-directed TNF-α inhibition may be of benefit in some asthmatic children.
Publication types
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Letter
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Research Support, N.I.H., Extramural
MeSH terms
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Adolescent
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Anti-Inflammatory Agents / therapeutic use
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Asthma / drug therapy
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Asthma / genetics*
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Asthma / immunology
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Asthma / pathology*
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Case-Control Studies
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Child
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Female
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Gene Expression / immunology
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Humans
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I-kappa B Kinase / genetics
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I-kappa B Kinase / immunology
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I-kappa B Proteins / genetics
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I-kappa B Proteins / immunology
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Male
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NF-KappaB Inhibitor alpha
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NF-kappa B / genetics
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NF-kappa B / immunology
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NF-kappa B p50 Subunit / genetics*
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NF-kappa B p50 Subunit / immunology
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Phenotype*
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Precision Medicine
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Respiratory Function Tests
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Severity of Illness Index
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Surveys and Questionnaires
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Triamcinolone / therapeutic use
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Tumor Necrosis Factor-alpha / genetics*
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Tumor Necrosis Factor-alpha / immunology
Substances
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Anti-Inflammatory Agents
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I-kappa B Proteins
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NF-kappa B
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NF-kappa B p50 Subunit
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NFKB1 protein, human
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NFKBIA protein, human
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Tumor Necrosis Factor-alpha
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NF-KappaB Inhibitor alpha
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Triamcinolone
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CHUK protein, human
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I-kappa B Kinase
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IKBKB protein, human