Characterization of a high TNF-α phenotype in children with moderate-to-severe asthma

J Allergy Clin Immunol. 2015 Jun;135(6):1651-4. doi: 10.1016/j.jaci.2014.08.054. Epub 2015 Feb 26.

Abstract

Systemic TNF-α expression is increased in a subset of children with moderate-to-severe asthma despite aggressive corticosteroid treatment and is associated with poor asthma control. Phenotypic-directed TNF-α inhibition may be of benefit in some asthmatic children.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Anti-Inflammatory Agents / therapeutic use
  • Asthma / drug therapy
  • Asthma / genetics*
  • Asthma / immunology
  • Asthma / pathology*
  • Case-Control Studies
  • Child
  • Female
  • Gene Expression / immunology
  • Humans
  • I-kappa B Kinase / genetics
  • I-kappa B Kinase / immunology
  • I-kappa B Proteins / genetics
  • I-kappa B Proteins / immunology
  • Male
  • NF-KappaB Inhibitor alpha
  • NF-kappa B / genetics
  • NF-kappa B / immunology
  • NF-kappa B p50 Subunit / genetics*
  • NF-kappa B p50 Subunit / immunology
  • Phenotype*
  • Precision Medicine
  • Respiratory Function Tests
  • Severity of Illness Index
  • Surveys and Questionnaires
  • Triamcinolone / therapeutic use
  • Tumor Necrosis Factor-alpha / genetics*
  • Tumor Necrosis Factor-alpha / immunology

Substances

  • Anti-Inflammatory Agents
  • I-kappa B Proteins
  • NF-kappa B
  • NF-kappa B p50 Subunit
  • NFKB1 protein, human
  • NFKBIA protein, human
  • Tumor Necrosis Factor-alpha
  • NF-KappaB Inhibitor alpha
  • Triamcinolone
  • CHUK protein, human
  • I-kappa B Kinase
  • IKBKB protein, human