A meta-analysis of resected metachronous second non-small cell lung cancer

Masatsugu Hamaji; Syed Osman Ali; Bryan M Burt

doi:10.1016/j.athoracsur.2014.11.033

A meta-analysis of resected metachronous second non-small cell lung cancer

Ann Thorac Surg. 2015 Apr;99(4):1470-8. doi: 10.1016/j.athoracsur.2014.11.033. Epub 2015 Feb 26.

Authors

Masatsugu Hamaji¹, Syed Osman Ali², Bryan M Burt³

Affiliations

¹ Department of Thoracic Surgery, Kyoto University Hospital, Shogoin, Sakyo-ku, Kyoto, Japan. Electronic address: mhamaji@kuhp.kyoto-u.ac.jp.
² Division of Cardiothoracic Surgery, Altru Hospital, Grand Forks, North Dakota.
³ Division of Thoracic Surgery, Department of Surgery, Baylor College of Medicine, Houston, Texas.

PMID: 25725930
DOI: 10.1016/j.athoracsur.2014.11.033

Abstract

This meta-analysis was designed to determine the effect of surgical treatment on overall survival of patients treated surgically for a second non-small cell lung cancer (NSCLC) that occurred after resection of an initial NSCLC. PubMed and Scopus databases were queried. Nine studies were identified. Meta-analyses revealed pooled operative mortality of 7% for the second resection, pooled 5-year overall survival of 46% after resection of the second NSCLC, and 79% after resection of the first NSCLC. These results suggest that surgical resection can be considered for patients who have a second primary NSCLC after resection of an initial lung cancer.

Publication types

Meta-Analysis
Review

MeSH terms

Carcinoma, Non-Small-Cell Lung / mortality*
Carcinoma, Non-Small-Cell Lung / pathology
Carcinoma, Non-Small-Cell Lung / surgery*
Disease-Free Survival
Humans
Lung Neoplasms / mortality*
Lung Neoplasms / pathology
Lung Neoplasms / surgery*
Male
Neoplasm Invasiveness / pathology
Neoplasm Staging
Neoplasms, Second Primary / mortality*
Neoplasms, Second Primary / pathology
Neoplasms, Second Primary / surgery*
Pneumonectomy / methods
Prognosis
Survival Analysis
Treatment Outcome