Chromatin methylation and cardiovascular aging

J Mol Cell Cardiol. 2015 Jun:83:21-31. doi: 10.1016/j.yjmcc.2015.02.011. Epub 2015 Feb 25.

Abstract

DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called "epigenetic drift", in parallel with a change in the methylated histone profile. Despite the large body of knowledge regarding age-dependent epigenetic changes, there are few reports related to this topic in the cardiovascular field. This review summarizes age-dependent changes in DNA and histone methylation with a specific focus on age-related cardiovascular diseases (CVDs).

Keywords: Aging; Cardiovascular disease; DNA methylation; Histone methylation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / genetics
  • Aging / metabolism*
  • Animals
  • Arrhythmias, Cardiac / genetics
  • Arrhythmias, Cardiac / metabolism*
  • Arrhythmias, Cardiac / pathology
  • Atherosclerosis / genetics
  • Atherosclerosis / metabolism*
  • Atherosclerosis / pathology
  • Chromatin / chemistry
  • Chromatin / metabolism*
  • DNA Methylation
  • Epigenesis, Genetic*
  • Heart Failure / genetics
  • Heart Failure / metabolism*
  • Heart Failure / pathology
  • Histones / genetics
  • Histones / metabolism
  • Humans
  • Myocardium / metabolism
  • Myocardium / pathology
  • Polycomb-Group Proteins / genetics
  • Polycomb-Group Proteins / metabolism
  • Signal Transduction

Substances

  • Chromatin
  • Histones
  • Polycomb-Group Proteins