Abstract
DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called "epigenetic drift", in parallel with a change in the methylated histone profile. Despite the large body of knowledge regarding age-dependent epigenetic changes, there are few reports related to this topic in the cardiovascular field. This review summarizes age-dependent changes in DNA and histone methylation with a specific focus on age-related cardiovascular diseases (CVDs).
Keywords:
Aging; Cardiovascular disease; DNA methylation; Histone methylation.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aging / genetics
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Aging / metabolism*
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Animals
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Arrhythmias, Cardiac / genetics
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Arrhythmias, Cardiac / metabolism*
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Arrhythmias, Cardiac / pathology
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Atherosclerosis / genetics
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Atherosclerosis / metabolism*
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Atherosclerosis / pathology
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Chromatin / chemistry
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Chromatin / metabolism*
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DNA Methylation
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Epigenesis, Genetic*
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Heart Failure / genetics
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Heart Failure / metabolism*
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Heart Failure / pathology
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Histones / genetics
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Histones / metabolism
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Humans
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Myocardium / metabolism
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Myocardium / pathology
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Polycomb-Group Proteins / genetics
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Polycomb-Group Proteins / metabolism
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Signal Transduction
Substances
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Chromatin
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Histones
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Polycomb-Group Proteins