Low-intensity late gadolinium enhancement predominates in hypertrophic cardiomyopathy

Clin Imaging. 2015 May-Jun;39(3):432-6. doi: 10.1016/j.clinimag.2015.01.001. Epub 2015 Jan 14.

Abstract

Aim: Assess the extent of low- versus high-intensity late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM).

Methods: Low- versus high-intensity LGE indexed volumes in 19 HCM patients were compared to 23 myocardial infarction (MI) patients.

Results: Total, low-, and high-intensity LGE volumes in HCM vs. MI were 7.6ml/m(2), 4.7, and 2.4 vs. 11.2, 2.5, and 7.1, respectively. Total LGE volume did not differ (P=.13), though low- and high-intensity did (P=.05, .004). 67% versus 26% of all LGE was low-intensity in HCM versus MI (P<.001).

Conclusions: LGE in HCM is predominantly low-intensity, so a low threshold may be the most appropriate.

Keywords: DCE; HCM; Hypertrophic cardiomyopathy; LGE; Late gadolinium enhancement.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cardiomyopathy, Hypertrophic / diagnosis*
  • Contrast Media*
  • Female
  • Gadolinium*
  • Humans
  • Image Enhancement / methods*
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Myocardium / pathology
  • Risk Factors
  • Young Adult

Substances

  • Contrast Media
  • Gadolinium