Disseminated emm Type 12 Group A Streptococcus and Review of Invasive Disease

Am J Med Sci. 2015 Nov;350(5):429-31. doi: 10.1097/MAJ.0000000000000400.

Abstract

The authors present a case of invasive group A Streptococcus (GAS) in a previously healthy 63-year-old male complicated by trans-esophageal echocardiogram negative endocarditis, septic arthritis, and multiple cerebral septic emboli. Despite antibiotics and drainage of his largest brain abscess, the patient expired. This case highlights the potential mortality from invasive GAS disease. Included is a review of current literature regarding invasive GAS that addresses its presentation, prevalence, virulence and treatment.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Arthritis, Infectious* / diagnosis
  • Arthritis, Infectious* / etiology
  • Brain Abscess* / diagnostic imaging
  • Brain Abscess* / etiology
  • Brain Abscess* / physiopathology
  • Brain Abscess* / surgery
  • Drainage / methods
  • Echocardiography / methods
  • Endocarditis* / diagnostic imaging
  • Endocarditis* / etiology
  • Fatal Outcome
  • Humans
  • Male
  • Middle Aged
  • Neurosurgical Procedures / methods*
  • Penicillin G / administration & dosage*
  • Streptococcal Infections* / blood
  • Streptococcal Infections* / complications
  • Streptococcal Infections* / physiopathology
  • Streptococcal Infections* / therapy
  • Streptococcus pyogenes* / isolation & purification
  • Streptococcus pyogenes* / pathogenicity
  • Synovial Fluid / microbiology
  • Tomography, X-Ray Computed / methods

Substances

  • Anti-Bacterial Agents
  • Penicillin G