A highly porous medical metal-organic framework constructed from bioactive curcumin

Chem Commun (Camb). 2015 Apr 4;51(26):5774-7. doi: 10.1039/c4cc10159f.

Abstract

A highly porous bio-MOF, medi-MOF-1, constructed from Zn and the pharmaceutical ingredient curcumin has been successfully synthesized. It can display permanent porosity with a surface area as high as ca. 3002 m(2) g(-1), which exhibits great potential in bioapplications. Its ibuprofen delivery ability, biodegradation and cytotoxicity were also studied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Curcumin / chemistry*
  • Curcumin / metabolism
  • Curcumin / pharmacology
  • Drug Carriers / chemistry*
  • Drug Carriers / metabolism
  • Drug Carriers / pharmacology
  • Drug Delivery Systems
  • Humans
  • Ibuprofen / chemistry
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / metabolism
  • Organometallic Compounds / pharmacology
  • Particle Size
  • Porosity
  • Structure-Activity Relationship
  • Surface Properties

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Drug Carriers
  • Organometallic Compounds
  • Curcumin
  • Ibuprofen