Abstract
A highly porous bio-MOF, medi-MOF-1, constructed from Zn and the pharmaceutical ingredient curcumin has been successfully synthesized. It can display permanent porosity with a surface area as high as ca. 3002 m(2) g(-1), which exhibits great potential in bioapplications. Its ibuprofen delivery ability, biodegradation and cytotoxicity were also studied.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Inflammatory Agents, Non-Steroidal / chemistry
-
Cell Line, Tumor
-
Cell Proliferation / drug effects
-
Curcumin / chemistry*
-
Curcumin / metabolism
-
Curcumin / pharmacology
-
Drug Carriers / chemistry*
-
Drug Carriers / metabolism
-
Drug Carriers / pharmacology
-
Drug Delivery Systems
-
Humans
-
Ibuprofen / chemistry
-
Organometallic Compounds / chemistry*
-
Organometallic Compounds / metabolism
-
Organometallic Compounds / pharmacology
-
Particle Size
-
Porosity
-
Structure-Activity Relationship
-
Surface Properties
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Drug Carriers
-
Organometallic Compounds
-
Curcumin
-
Ibuprofen