Anti-N antibody reacting at 37°C: An unusual occurrence interfering with routine testing: Two interesting cases

Vijay Kumawat; Ashish Jain; Neelam Marwaha; Ratti Ram Sharma

doi:10.4103/0973-6247.150964

Anti-N antibody reacting at 37°C: An unusual occurrence interfering with routine testing: Two interesting cases

Asian J Transfus Sci. 2015 Jan-Jun;9(1):92-3. doi: 10.4103/0973-6247.150964.

Authors

Vijay Kumawat¹, Ashish Jain², Neelam Marwaha², Ratti Ram Sharma²

Affiliations

¹ Department of Transfusion Medicine, Citizens Hospital, Nallagandla, Serilingampally, Hyderabad, India.
² Department of Transfusion Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Abstract

Most anti-N antibodies are naturally occurring, IgM antibodies, and not active above 25°C and are not clinically significant but IgG anti- N has also been described. Immune anti-N resulting from multiple transfusions does occur & has been implicated as the cause of hemolytic transfusion reactions and mild hemolytic disease of fetus and newborn. Anti- N reacting at room temperature can be a cause for ABO blood group discrepancy.

Keywords: Anti-N antibody; naturally occurring anti-N; warm reacting antibody.

Publication types

Case Reports