Abstract
A hallmark of ageing is dysfunction in nutrient signalling pathways that regulate glucose homeostasis, negatively affecting whole-body energy metabolism and ultimately increasing the organism's susceptibility to disease. Maintenance of insulin sensitivity depends on functional mitochondrial networks, but is compromised by alterations in mitochondrial energy metabolism during ageing. Here we discuss metabolic paradigms that influence mammalian longevity, and highlight recent advances in identifying fundamental signalling pathways that influence metabolic health and ageing through mitochondrial perturbations.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Energy Metabolism / genetics*
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Gene Expression Regulation
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Glucose / metabolism
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Homeostasis
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Humans
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Insulin / metabolism*
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Insulin Resistance
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Longevity / genetics*
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Metabolic Diseases / genetics
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Metabolic Diseases / metabolism
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Metabolic Diseases / pathology
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Mitochondria / genetics
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Mitochondria / metabolism*
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Mitochondrial Proteins / genetics
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Mitochondrial Proteins / metabolism*
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Neoplasms / genetics
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Neoplasms / metabolism
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Neoplasms / pathology
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Neurodegenerative Diseases / genetics
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Neurodegenerative Diseases / metabolism
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Neurodegenerative Diseases / pathology
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Signal Transduction
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Unfolded Protein Response
Substances
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Insulin
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Mitochondrial Proteins
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Glucose