A biocompatible porous Mg-gallate metal-organic framework as an antioxidant carrier

Chem Commun (Camb). 2015 Apr 7;51(27):5848-51. doi: 10.1039/c5cc00745c. Epub 2015 Feb 27.

Abstract

A microporous magnesium gallate MOF was prepared from highly biocompatible reagents under environmentally friendly conditions. Its slow degradation in physiological fluids leads to the release of gallic acid and hence a high antioxidant activity, which was illustrated in the HL-60 cell line.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Cell Survival / drug effects
  • Coordination Complexes / chemical synthesis*
  • Culture Media / chemistry
  • Drug Carriers / chemical synthesis*
  • Drug Liberation
  • Drug Stability
  • Gallic Acid / chemistry
  • Gallic Acid / pharmacology*
  • Green Chemistry Technology
  • HL-60 Cells
  • Humans
  • Kinetics
  • Magnesium / chemistry*
  • Oxidants / antagonists & inhibitors
  • Oxidants / pharmacology
  • Porosity
  • Reactive Oxygen Species / antagonists & inhibitors*
  • Reactive Oxygen Species / metabolism
  • Tetradecanoylphorbol Acetate / antagonists & inhibitors
  • Tetradecanoylphorbol Acetate / pharmacology

Substances

  • Antioxidants
  • Coordination Complexes
  • Culture Media
  • Drug Carriers
  • Oxidants
  • Reactive Oxygen Species
  • Gallic Acid
  • Magnesium
  • Tetradecanoylphorbol Acetate