The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model

J Int Med Res. 2015 Jun;43(3):350-5. doi: 10.1177/0300060515569287. Epub 2015 Feb 25.

Abstract

Objective: To investigate the antiallodynic effects of thioctic acid in vincristine-induced neuropathy in rats.

Methods: Neuropathy was induced in Sprague-Dawley rats via vincristine intraperitoneal injection. After 15 days, rats were investigated for the presence of mechanical and cold allodynia, and those with allodynia received intraperitoneal injection with normal saline or 1, 5, or 10 mg/kg thioctic acid. Mechanical and cold allodynia were assessed before treatment and at 15, 30, 60, 90, 150 and 180 min after treatment.

Results: Mechanical and cold allodynia were reduced by thioctic acid injection. The duration of effect increased with thioctic acid dose.

Conclusion: Thioctic acid may be an effective treatment for vincristine-induced neuropathy.

Keywords: Thioctic acid; neuropathy; pain; vincristine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use*
  • Antioxidants / therapeutic use*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Hyperalgesia / chemically induced
  • Hyperalgesia / drug therapy*
  • Inflammation / chemically induced
  • Inflammation / drug therapy*
  • Neuralgia / drug therapy
  • Pain Measurement
  • Peripheral Nervous System Diseases / drug therapy
  • Rats
  • Rats, Sprague-Dawley
  • Thioctic Acid / therapeutic use*
  • Vincristine / adverse effects

Substances

  • Anti-Inflammatory Agents
  • Antioxidants
  • Vincristine
  • Thioctic Acid