Copper-catalyzed ortho-halogenation of arenes and heteroarenes directed by a removable auxiliary

Chem Commun (Camb). 2015 Mar 25;51(24):5093-6. doi: 10.1039/c5cc00531k.

Abstract

Copper-catalyzed ortho-halogenation of C(sp(2))-H bonds directed by a PIP directing group with NXS (X = Cl, Br, I) has been developed. The reaction is scalable and tolerates a broad range of functional groups and heteroarenes, providing an efficient access to halogenated arenes and heteroarenes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzene Derivatives / chemistry*
  • Catalysis
  • Copper / chemistry*
  • Halogenation
  • Heterocyclic Compounds / chemistry*
  • Hydrocarbons, Halogenated / chemical synthesis*
  • Hydrocarbons, Halogenated / chemistry
  • Molecular Structure
  • Propylamines / chemistry*

Substances

  • Benzene Derivatives
  • Heterocyclic Compounds
  • Hydrocarbons, Halogenated
  • Propylamines
  • Copper