Two new stemphol sulfates from the mangrove endophytic fungus Stemphylium sp. 33231

J Antibiot (Tokyo). 2015 Aug;68(8):501-3. doi: 10.1038/ja.2015.16. Epub 2015 Feb 25.

Abstract

Two new stemphol sulfates, stemphol A (1) and stemphol B (2), along with known compound stemphol (3) were isolated from the EtOAc extract of the fermentation of an endophytic Stemphylium sp. 33231. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The isolated compounds exhibited potent antibacterial activities against six terrestrial pathogenic bacteria with MIC values of 0.6-10 μg ml(-1). The inhibitory activities of all compounds against five cancer cell lines were evaluated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Ascomycota / metabolism*
  • Bacteria / drug effects*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Endophytes / metabolism*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Resorcinols / chemistry
  • Resorcinols / isolation & purification*
  • Sulfates / chemistry
  • Sulfates / isolation & purification*

Substances

  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Resorcinols
  • Sulfates
  • stemphol