Effect of clinical factors and gene polymorphism of CYP2C19*2, *17 and CYP4F2*3 on early stent thrombosis

Pharmacogenomics. 2015;16(3):181-9. doi: 10.2217/pgs.14.165.

Abstract

Aim: To determine the main clinical and genetic factors having impact on early coronary stent thrombosis.

Materials & methods: Genotyping of CYP2C19*2, *17 and CYP4F2*3 in patients with (n = 31) and without stent thrombosis (n = 456) was performed. Clinical and genetic data were analyzed by binary logistic regression.

Results: Smoking (OR: 0.317; 95% CI: 0.131-0.767), high-density lipoprotein level in mmol/l (OR: 0.142; 95% CI: 0.040-0.506), CYP2C19*2*2 versus *1*1 and *1*2 genotype (OR: 11.625; 95% CI: 3.498-38.633), CYP4F2 AA versus GA and GG genotype (OR: 3.532; 95% CI: 1.153-10.822) were associated with early stent thrombosis.

Conclusion: For the first time we have identified a clinically important polymorphism (CYP4F2 G1347A) that was independently associated with early stent thrombosis. Original submitted 18 August 2014; Revision submitted 10 November 2014.

Keywords: cardiovascular disease; molecular biology; pharmacogenetics; polymerase chain reaction; stent; thrombosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aspirin / administration & dosage
  • Case-Control Studies
  • Clopidogrel
  • Cytochrome P-450 CYP2C19 / genetics*
  • Cytochrome P-450 Enzyme System / genetics*
  • Cytochrome P450 Family 4
  • Female
  • Genotype
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Models, Genetic
  • Percutaneous Coronary Intervention / adverse effects*
  • Platelet Aggregation Inhibitors / administration & dosage
  • Polymorphism, Genetic
  • Risk Factors
  • Stents / adverse effects*
  • Thrombosis / enzymology
  • Thrombosis / etiology*
  • Thrombosis / genetics*
  • Ticlopidine / administration & dosage
  • Ticlopidine / analogs & derivatives

Substances

  • Platelet Aggregation Inhibitors
  • Cytochrome P-450 Enzyme System
  • Clopidogrel
  • CYP2C19 protein, human
  • Cytochrome P-450 CYP2C19
  • Cytochrome P450 Family 4
  • CYP4F2 protein, human
  • Ticlopidine
  • Aspirin