Influence of chronic intermittent hypoxia on growth associated protein 43 expression in the hippocampus of young rats

Yan Chen; Chunling Zhao; Chunlai Zhang; Lirong Luo; Guang Yu

doi:10.3969/j.issn.1673-5374.2012.16.006

Influence of chronic intermittent hypoxia on growth associated protein 43 expression in the hippocampus of young rats

Neural Regen Res. 2012 Jun 5;7(16):1241-6. doi: 10.3969/j.issn.1673-5374.2012.16.006.

Authors

Yan Chen¹, Chunling Zhao¹, Chunlai Zhang¹, Lirong Luo², Guang Yu¹

Affiliations

¹ Department of Physiology, Luzhou Medical College, Luzhou 646000, Sichuan Province, China.
² Functional Experiment Center of Luzhou Medical College, Luzhou 646000, Sichuan Province, China.

PMID: 25709622
PMCID: PMC4336958
DOI: 10.3969/j.issn.1673-5374.2012.16.006

Abstract

This study aimed to explore the pathological change to hippocampal neurons and the expression of growth associated protein 43 in 21-day-old young rats following chronic intermittent hypoxia. Hematoxylin-eosin staining results showed varying degrees of degeneration and necrosis in hippocampal neurons depending on the modeling time. Immunohistochemistry revealed that growth associated protein 43 expression in young rats following chronic intermittent hypoxia decreased, but that levels were still higher than those of normal rats at each time point, especially 4 weeks after modeling. During 1-5 weeks after modeling, a slow growth in rat weight was observed. Experimental findings indicate that chronic intermittent hypoxia may induce growth dysfunction and necrosis of hippocampal neurons, as well as increase the expression of growth associated protein 43 in young rats.

Keywords: brain injury; chronic intermittent hypoxia; growth associated protein 43; hippocampus; neural regeneration; obstructive sleep apnea hypopnea syndrome; young rats.