The topical corticosteroid classification called into question: towards a new approach

Exp Dermatol. 2015 May;24(5):393-5. doi: 10.1111/exd.12677.

Abstract

Vasoconstrictor assay described in 1962 was an interesting assessment of potency of topical corticosteroids at the beginning of these new therapies, however knowledge and technology have evolved and the classification should follow. A topical corticosteroids with a strong vasoconstrictor effect, as determined by vasoconstrictor assay, has not necessary a strong anti-inflammatory effect. Therefore a specific classification adapted to the therapeutic target is needed to be more efficient and thus reduce side effects and corticophobia.

Keywords: classification; potency; topical corticosteroid; vasoconstrictor assay.

Publication types

  • Letter

MeSH terms

  • Administration, Topical
  • Adrenal Cortex Hormones / administration & dosage*
  • Adrenal Cortex Hormones / classification*
  • Adrenal Cortex Hormones / pharmacokinetics
  • Dermatologic Agents / administration & dosage*
  • Dermatologic Agents / classification*
  • Dermatologic Agents / pharmacokinetics
  • Humans
  • Skin Diseases / drug therapy
  • Therapeutic Equivalency
  • Vasoconstriction / drug effects

Substances

  • Adrenal Cortex Hormones
  • Dermatologic Agents