Abstract
Thin, nonhemagglutinating fimbriae have been demonstrated on 100% of the clinical isolates of nontypeable Haemophilus influenzae recovered from children with chronic otitis media tested in this laboratory (L. O. Bakaletz, B.M. Tallan, T.M. Hoepf, T.F. DeMaria, H.G. Birck, and D.J. Lim, Infect. Immun. 56:331-335, 1988). Chinchillas with induced otitis media responded to this surface-located antigen of both the infecting and a heterologous strain. Antibodies were found in both serum and middle ear fluids.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Bacterial / biosynthesis
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Antigens, Bacterial / immunology*
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Bacterial Outer Membrane Proteins / immunology*
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Bacterial Outer Membrane Proteins / ultrastructure
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Blotting, Western
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Chinchilla
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Disease Models, Animal
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Fimbriae, Bacterial / immunology*
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Fimbriae, Bacterial / ultrastructure
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Haemophilus influenzae / immunology*
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Otitis Media / immunology
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Bacterial Outer Membrane Proteins