Crystal structure of 1,7,8,9-tetra-chloro-4-(2-fluoro-benz-yl)-10,10-dimeth-oxy-4-aza-tri-cyclo-[5.2.1.0(2,6)]dec-8-ene-3,5-dione

Jia-Liang Zhong; Jia-Wei Hou; Li-Hong Liu; He Liu

doi:10.1107/S2056989014026279

Crystal structure of 1,7,8,9-tetra-chloro-4-(2-fluoro-benz-yl)-10,10-dimeth-oxy-4-aza-tri-cyclo-[5.2.1.0(2,6)]dec-8-ene-3,5-dione

Acta Crystallogr E Crystallogr Commun. 2015 Jan 1;71(Pt 1):o32. doi: 10.1107/S2056989014026279.

Authors

Jia-Liang Zhong¹, Jia-Wei Hou¹, Li-Hong Liu², He Liu²

Affiliations

¹ Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, People's Republic of China.
² Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, People's Republic of China.

Abstract

In the title compound, C17H12Cl4FNO4, the configuration of the cyclo-alkene skeleton is endo,cis. The benzene ring is twisted by 71.01 (11)° from the attached pyrrolidine ring. In the crystal, one of the methine groups of the fused-ring system forms a weak C-H⋯O hydrogen bond. The other methine groups participates in a C-H⋯F inter-action to the same adjacent mol-ecule. Together, these generate [010] chains.

Keywords: C—H⋯F interaction; biochemical activity; crystal structure; hydrogen bonding; tricyclo[5,2,1,02,6]dec-8-ene-3,5-dione.