Hemangiomas and the eye

Clin Dermatol. 2015 Mar-Apr;33(2):170-82. doi: 10.1016/j.clindermatol.2014.10.009.

Abstract

Infantile hemangiomas are a common vascular birthmark with heterogeneous presentations and unique growth characteristics with early rapid growth and eventual self-involution. Hemangiomas that develop around the eye have the potential for inducing amblyopia by several mechanisms and may eventually result in permanent visual impairment in otherwise healthy infants. Segmental periocular hemangiomas carry the additional risk of associated structural anomalies and PHACE syndrome. In recent years, the treatment of periocular hemangiomas has been revolutionized by the serendipitous discovery of the effectiveness of beta-blockers (systemic and topical), with most experts viewing these as first-line therapies. The management of periocular hemangiomas should involve a close partnership between an ophthalmologist and dermatologist or other relevant specialists familiar with the unique clinical features, differential diagnosis, treatment approaches, and potential complications.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Eyelid Neoplasms / diagnosis*
  • Eyelid Neoplasms / drug therapy
  • Eyelid Neoplasms / epidemiology
  • Facial Neoplasms / drug therapy
  • Facial Neoplasms / epidemiology
  • Facial Neoplasms / pathology*
  • Female
  • Hemangioma, Capillary / diagnosis*
  • Hemangioma, Capillary / drug therapy*
  • Hemangioma, Capillary / epidemiology
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Magnetic Resonance Imaging / methods
  • Male
  • Neoplastic Syndromes, Hereditary / diagnosis*
  • Neoplastic Syndromes, Hereditary / drug therapy*
  • Neoplastic Syndromes, Hereditary / epidemiology
  • Prognosis
  • Propranolol / therapeutic use
  • Remission, Spontaneous

Substances

  • Adrenal Cortex Hormones
  • Propranolol

Supplementary concepts

  • Hemangioma, capillary infantile