Novel molecular imprinted polymers over magnetic mesoporous silica microspheres for selective and efficient determination of protocatechuic acid in Syzygium aromaticum

Lianwu Xie; Junfang Guo; Yuping Zhang; Yunchu Hu; Qingping You; Shuyun Shi

doi:10.1016/j.foodchem.2015.01.069

Novel molecular imprinted polymers over magnetic mesoporous silica microspheres for selective and efficient determination of protocatechuic acid in Syzygium aromaticum

Food Chem. 2015 Jul 1:178:18-25. doi: 10.1016/j.foodchem.2015.01.069. Epub 2015 Jan 21.

Authors

Lianwu Xie¹, Junfang Guo², Yuping Zhang², Yunchu Hu³, Qingping You², Shuyun Shi⁴

Affiliations

¹ College of Sciences, Central South University of Forestry and Technology, Changsha 410004, China; College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China. Electronic address: xiecsu@126.com.
² College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
³ College of Sciences, Central South University of Forestry and Technology, Changsha 410004, China.
⁴ College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China. Electronic address: shuyshi@gmail.com.

PMID: 25704678
DOI: 10.1016/j.foodchem.2015.01.069

Abstract

Improving sites accessibility can increase the binding efficiency of molecular imprinted polymers (MIPs). In this work, we firstly synthesized MIPs over magnetic mesoporous silica microspheres (Fe3O4@mSiO2@MIPs) for the selective recognition of protocatechuic acid (PCA). The resulting Fe3O4@mSiO2@MIPs were characterized by transmission electron microscopy (TEM), Fourier transform infrared spectrometer (FT-IR), thermo-gravimetric analysis (TGA), Brunauer-Emmett-Teller (BET), and vibration sample magnetometer (VSM), and evaluated by adsorption isotherms/kinetics and competitive adsorption. The maximum adsorption capacity of PCA on Fe3O4@mSiO2@MIPs was 17.2mg/g (2.3 times that on Fe3O4@SiO2@MIPs). In addition, Fe3O4@mSiO2@MIPs showed a short equilibrium time (140min), rapid magnetic separation (5s) and high stability (retained 94.4% after six cycles). Subsequently, Fe3O4@mSiO2@MIPs were successfully applied for the selective and efficient determination of PCA (29.3μg/g) from Syzygium aromaticum. Conclusively, we combined three advantages into Fe3O4@mSiO2@MIPs, namely, Fe3O4 core for quick separation, mSiO2 layer for enough accessible sites, and surface imprinting MIPs for fast binding and excellent selectivity, to extract PCA from complex systems.

Keywords: Magnetic microsphere; Mesoporous silica; Molecularly imprinted polymers; Protocatechuic acid; Syzygium aromaticum.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hydroxybenzoates / chemistry*
Magnetic Phenomena
Microscopy, Electron, Transmission / methods*
Microspheres
Molecular Imprinting / methods*
Plant Extracts / chemistry*
Polymers / chemistry*
Silicon Dioxide / chemistry*
Spices

Substances

Hydroxybenzoates
Plant Extracts
Polymers
protocatechuic acid
Silicon Dioxide