Five new diarylheptanoids from the rhizomes of Curcuma kwangsiensis and their antiproliferative activity

Fitoterapia. 2015 Apr:102:67-73. doi: 10.1016/j.fitote.2015.02.004. Epub 2015 Feb 20.

Abstract

Five new diarylheptanoids (1-5), along with nine known ones (6-14), were isolated from the rhizomes of Curcuma kwangsiensis. Their structures were established on the basis of spectroscopic analyses. Compounds 1-3 were cyclic diarylheptanoids rarely discovered from C. kwangsiensis. Of all the isolated compounds, compound 4 showed moderate antiproliferative activity on HH and HaCaT cells.

Keywords: Antiproliferation; Curcuma kwangsiensis; Diarylheptanoids; HH cells; HaCaT cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Cell Proliferation / drug effects*
  • Curcuma / chemistry*
  • Diarylheptanoids / chemistry*
  • Diarylheptanoids / isolation & purification
  • Humans
  • Molecular Structure
  • Rhizome / chemistry*

Substances

  • Diarylheptanoids